Professor Mathews Makes Breakthrough in Cure for Diabetes
Dr. Suresh Mathews discovered that a blood protein called fetuin may play a significant role in regulation of glucose levels. Glucose may be regulated by blocking this protein, serving as treatment for type II diabetes and obesity.
Dr. Mathews’ lab focuses on the fetuin molecule which is secreted by the liver and plays a vital role in inhibiting insulin activity. Fetuin is also linked to metabolic syndromes. Mathews’ work could potentially affect obesity rates as well.
“Fetuin interferes with the normal process by blocking the effects of insulin,� said Mathews. “A goal of our research is to determine exact mechanisms involved in how turning fetuin off works to improve insulin action and obesity resistance. If we can find a mechanism to block this protein in humans, it could lead to development of a treatment for type II diabetes and obesity.�
The focus of Mathews’ research centers on metabolic diseases, including type II diabetes, insulin resistance, and gene expression in obese animals. The American Diabetes Association offered grants since 2004 and will continue funding his research until next summer.
Type II diabetes is classified as a metabolic disorder. Glucose 
levels are elevated in the blood and the body cannot produce proper amounts of insulin. Fetuin acts as the initial insulin producer, activating the insulin receptor. Mathews’ studies indicate that rats fed high fat diets have increased levels of fetuin. Genetically altered mice lacking fetuin demonstrate improved insulin action and are resistant to weight gain.
“We have some important discoveries using our animal model,� said Mathews. “The next step is to examine this phenomenon in humans.�
Mathews began his research several years ago after receiving his doctorate at the Wayne State University School of Medicine in Detroit, Michigan. He recognizes that the prevention of type II diabetes is possible with diet regulation and regular physical activity, yet millions of people worldwide are afflicted with the disease. He hopes to find a cure and save millions of lives.
“Old-school ideas are constantly being challenged in today’s world,â€? said Mathews. “Novel strategies and techniques encourage scientists to ‘re-search’ the well-beaten path.â€?
Auburn University realizes the benefits of interdisciplinary 
research discussions centered on diabetes. The College of Veterinary Medicine established the Boshell Diabetes and Metabolic Diseases Research Program to create collaboration among various research teams at Auburn.
The mission of Boshell research serves to “facilitate cross-disciplinary scientific discussion, support the study of new ideas, foster the development of investigators new to the field of diabetes, and expand the overall base of diabetes investigation at the University,� according to their Web site.
The team hopes to improve millions of lives through discovering a cure for type II diabetes. Meetings are held every Wednesday afternoon to explore new ideas, discuss breakthroughs in research methods and foster relationships among over 20 group members.
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